Publications
Grants
Active:
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Title: Endogenous steroid hormones as mediators of interorgan communication with the musculoskeletal system
Source: NIH/NIA U01 AG086158-01
Goal: Test the role of adrenal-derived endogenous glucocorticoids and signaling through the GR/MR in musculoskeletal aging and bone-mediated interorgan communication
Title: Novel mechanisms of muscle and bone loss with HIV infection, antiretroviral therapy, and aging
Source: NIH/OD R01 AR082307-01A1
Goal: Test the role of AhR in mediating musculoskeletal effects of HIV and anti-retroviral therapy
Title: Kynurenine accumulation stimulates loss of muscle and bone function with aging
Source: NIH/NIA (P01 Program project grant) P01-AG036675
Goal: Project 4: “Kynurenine-AhR crosstalk with nuclear receptor mediated signaling in skeletal aging.” Test whether the sexually dimorphic effects of Kyn are attributed to crosstalk between Kyn/AhR ligand-regulated, DNA-binding transcription factors in the nuclear receptor superfamily including the estrogen receptor (ER alpha/beta) and the glucocorticoid receptor (GR).
Title: Kynurenine accumulation stimulates loss of muscle and bone function with aging
Source: NIH/NIA (P01 Program project grant) P01-AG036675
Goal: Core B: “Functional Outcomes Core. Provide a standardized set of musculoskeletal assay services to facilitate completion of the broader goals and objections of the Program Project goals and specific aims, and develop new technologies in support of future research activities related to the objectives of the Program Project grant.
Title: Skyscan 1276
Source: NIH/OD S10 OD036250-01
Goal: Obtain an in vivo micro-computed tomography instrument for Augusta University
Title: Osteocyte plasma membrane disruptions in skeletal adaptation to loading and unloading.
Source: NASA Space Biology Grant #80NSSC21K0274
Goal: Understand the effects of physical inactivity (disuse) on formation and repair of osteocyte PMD
Title: Age-Related Kynurenine Accumulation Impairs miRNA and Hdac Epigenetic Regulation of the SDF-1 Axis Resulting in Bone Loss
Source: NIH / NIA R01AG067510
Goal: Understand the relationship between Hdac3, SDF-1, and miR29b-1-5p in the pathophysiology of aging bone marrow stem cells
Title: Temporary plasma membrane disruptions in corneal epithelium and keratocytes
Source: NIH/NEI R01 EY034851
Goal: Test the formation of transient membrane disruptions in the mechanobiology of the anterior eye
Completed:
Title: Use of scRNAseq to define skeletal aging patterns in the heterogenous bone marrow microenvironment
Source: 10X Genomics / GCC Integrated Genomics Core
Goal: Obtain scRNAseq data from bone marrow-derived MSC isolated from old (21 months) and young adult (6 months) male and female C57BL/6J mice to support extramural grant applications
Title: Nutritional effects on bone growth in aging
Source: NIH/NIA (P01 Program project grant) P01-AG036675
Goal: Project 4: “Role of Osteoprogenitor Hdac3 in Bone Marrow Adiposity.” Determine how Hdac3 expression in osteoprogenitors regulates lipid storage by osteoblast lineage cells during aging and nutritional interventions
Title: Marrow Adiposity: Bone, Aging, and Beyond 6th Int’l Conference of BMAS
Source: NIH / NIA R13AG069353
Goal: Organize an international conference on the biology of bone marrow adiposity
Title: Mechanosensation in bone through osteocyte plasma membrane disruptions
Source: National Science Foundation NSF 1727949
Goal: Investigate whether osteocyte plasma membrane disruptions (cell membrane tears) occur during physiological mechanical loading and whether this mechanism may serve as a way for osteocytes to sense mechanical loading in their environment.
Title: Role of osteoblastic Hdac3 in the regulation of systemic energy metabolism
Source: American Diabetes Association (Junior Faculty Development Award) 1-16-JDF-062
Goal: Determine how osteoblastic Hdac3 may regulate hepatic RANKL signaling and systemic metabolism via skeletal production of osteoprotegerin
Title: Effects of osteoblastic Hdac3 expression on hepatic inflammation and insulin sensitivity via OPG
Source: American Diabetes Association (Minority Undergraduate Internship Award) 1-17-MUI-005
Goal: Determine the effects of skeletal Hdac3 expression on hepatic inflammation through OPG
Title: Pilot and Feasibility Study: Regulation of hepatic insulin action by skeletal Hdac3 and osteoprotegerin (Subaward H412621701, P30DK050456-19)
Source: National Institutes of Health / NIDDK / Minnesota Obesity Center
Goal: Determine how osteoblastic Hdac3 may regulate hepatic inflammation via skeletal production of osteoprotegerin
Title: Modulation of Wnt Signaling by Runx2 and Axin2 Interaction in Postnatal Fracture Repair (Career Development Award)
Source: Center for Regenerative Medicine, Mayo Clinic
Goal: Understand the mechanisms by which Runx2 protein represses Axin2 transcription to promote osteoblast and chondrocyte maturation in postnatal endochondral and intramembranous ossification.